منابع مشابه
TPC1 Knockout Knocks Out TPC1.
Robert Hooper, Dev Churamani, Sean M. Davidson, Yaping Lin-Moshier, Timothy F. Walseth, Sandip Patel, Jonathan S. Marchant Department of Cell and Developmental Biology, University College London, London, United Kingdom; Department of Medicine, Hatter Cardiovascular Institute, University College London, London, United Kingdom; Department of Pharmacology, University of Minnesota Medical School, M...
متن کاملDissection of the RET/β-catenin interaction in the TPC1 thyroid cancer cell line.
The RET receptor tyrosine kinase is a member of the cadherin superfamily and plays a pivotal role in cell survival, differentiation and proliferation. Currently, 12 ret/ptc chimeric oncogenes, characterized by the fusion between the intracellular domain of RET and different activating genes, which can cause ligand-independent dimerization and constitutive activation, have been described. β-cate...
متن کاملBerberine Inhibited the Growth of Thyroid Cancer Cell Lines 8505C and TPC1
PURPOSE Thyroid cancer is the most common malignancy in Korean females and can be treated with good prognosis. However, drugs to treat aggressive types of thyroid cancer such as poorly differentiated or anaplastic thyroid cancer have not yet been established. To that end, we analyzed the effects of berberine on human thyroid cancer cell lines to determine whether this compound is useful in the ...
متن کاملMicroRNA-145 inhibits human papillary cancer TPC1 cell proliferation by targeting DUSP6.
MicroRNAs (miRNAs) are small, non-coding RNAs that modulate gene expression by negatively regulating the stability or translational efficiency of their target mRNAs. The aim of this study was to investigate the expression of microRNA-145 (miR-145) in human papillary thyroid cancer and its potential function. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to...
متن کاملEffects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line
BACKGROUND The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gai...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2015
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00020-15